The Link Between Parathyroid Hormone, Myocardial Fibrosis and Diastolic Dysfunction in Individuals with Mild Renal Impairment
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چکیده
منابع مشابه
Medalists with extreme duration of type 1 diabetes exhibit only mild diastolic dysfunction and myocardial fibrosis.
Medalists are a unique subset of patients with more than 50 years of type 1 diabetes. One would expect these patients to have significant microvascular and macrovascular complications. However, the Joslin observational study showed that of their medalists, a substantial proportion remained free of proliferative diabetic retinopathy (42.6%), nephropathy (86.9%), and neuropathy (39.4%) (1). Wheth...
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Impaired renal function with loss of nephron number in chronic renal disease (CKD) is associated with increased cardiovascular morbidity and mortality. However, the structural and functional cardiac response to early and mild reduction in renal mass is poorly defined. We hypothesized that mild renal impairment produced by unilateral nephrectomy (UNX) would result in early cardiac fibrosis and i...
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Excessive myocardial fibrosis deteriorates diastolic function in hypertensive hearts. Involvement of macrophages is suggested in fibrotic process in various diseased situations. We sought to examine the role of macrophages in myocardial remodeling and cardiac dysfunction in pressure-overloaded hearts. In Wistar rats with suprarenal aortic constriction, pressure overload induced perivascular mac...
متن کاملComparison of serum parathyroid hormone level between patients with acute myocardial infarction, unstable angina, and normal coronary function
Background: Nowadays, cardiovascular diseases (CVDs) are among the most common causes of mortalities worldwide. Parathyroid hormone (PTH) has an important role in the pathogenesis of CVDs. The aim of the current study was to compare serum PTH levels between patients with acute myocardial infarction (MI), unstable angina, and normal coronary function. Methods: This descriptive and analytic stud...
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Janet Wei, Michael D. Nelson, Edward W. Szczepaniak, Laura Smith, Puja K. Mehta, Louise E. J. Thomson, Daniel S. Berman, Debiao Li, C. Noel Bairey Merz, and Lidia S. Szczepaniak Barbra Streisand Women’s Heart Center, Cedars-Sinai Heart Institute, Los Angeles, California; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; and S. Mark Taper Foundation Ima...
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ژورنال
عنوان ژورنال: Heart, Lung and Circulation
سال: 2012
ISSN: 1443-9506
DOI: 10.1016/j.hlc.2012.05.564